Effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease.
Clinical evidence update from PloS one
Clinical Context
Peer-reviewed veterinary literature continues to shape everyday decision-making for feline patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.
What the Study Evaluated
A study published in PloS one in 2026 evaluated effect of dietary Ca:P ratio on ionized calcium and calcium homeostasis in cats with early-stage chronic kidney disease..
Key Findings
The aim of the study was to compare two renal foods with different Ca:P ratios on manifestation of hypercalcemia and regulation of calcium homeostasis in cats with chronic kidney disease (CKD). Nine cats (11.0 ± 2.0 y) with naturally-occurring IRIS Stage I or II CKD were fed a senior wellness food for 28-days, then randomized into two groups and fed either a food providing 1.8 g/Mcal Ca, 1.3 g/Mcal P, and Ca:P ratio of 1.4:1 (MOD-Ca:P), or a food providing 2.4 g/Mcal Ca, 1.3 g/Mcal P, and Ca:P ratio of 1.8:1 (HIGH-Ca:P) for 56 days. After a 28-day washout period, cats were crossed over to the other test food. Blood and urine samples were...
Why It Matters for Veterinary Professionals
For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for feline patients.
Practical Interpretation
The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.
Clinical Takeaway
Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.
Read the full article here.
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