Increased serum amyloid A and urinary kidney injury marker-1 concentrations in cats with pyelonephritis: a diagnostic accuracy study.
Clinical evidence update from The Journal of small animal practice
Clinical Context
Peer-reviewed veterinary literature continues to shape everyday decision-making for feline patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.
What the Study Evaluated
A study published in The Journal of small animal practice in 2026 evaluated increased serum amyloid A and urinary kidney injury marker-1 concentrations in cats with pyelonephritis: a diagnostic accuracy study..
Key Findings
To investigate the discriminatory potential of serum amyloid A, neutrophil:lymphocyte ratio, monocyte:lymphocyte ratio and assess renal tubular injury in cats with pyelonephritis. Diagnostic accuracy study using samples from prospectively enrolled cats and stored material. Cats were classified according to diagnosis as pyelonephritis, ureteral obstruction, chronic kidney disease, subclinical bacteriuria, cystitis, or healthy. Serum amyloid A, neutrophil:lymphocyte ratio, monocyte:lymphocyte ratio and urinary kidney injury marker-1 were compared across groups. Receiver operating characteristic curve analysis assessed the performance of...
Why It Matters for Veterinary Professionals
For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for feline patients.
Practical Interpretation
The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.
Clinical Takeaway
Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.
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