Chronic use of deslorelin in dogs
Deslorelin is currently registered for the induction of temporary infertility in male dogs, male cats, male ferrets and also prepubertal female dogs, but research has shown its usefulness for other conditions requiring chronic treatment.
This paper presents six cases of dogs chronically treated with deslorelin for indications such as benign prostatic hyperplasia, control of fertility, abnormal reproductive behavior and urinary incontinence.
All animals were in good health during treatment. Treatment duration was two to nine years. No short-term side effects were observed except for flare-up reactions, which were observed only in one in four intact males.
Two dogs developed a neoplasia: a spayed bitch treated for urinary incontinence developed a pituitary carcinoma, and an intact male dog implanted for control of fertility developed a bladder carcinoma. While the pituitary carcinoma seems unlikely to be related to deslorelin, the bladder carcinoma could be due to the neutered condition of the dog (which was treated for nine years) as urinary tract neoplasia is more common in dogs following gonadectomy.
Chronic treatment with deslorelin is regarded as safe when an animal is being treated for life. The possibility that a pause in the treatment might be helpful for the animal should be investigated.
Stefano Romagnoli, et al. “Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).” Animals (Basel). 2023 Jan 12;13(2):265. doi: 10.3390/ani13020265.
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