Low-fat diet monotherapy in dogs with presumptive protein-losing enteropathy
For dogs with protein-losing enteropathy (PLE) and evidence of lymphangiectasia, the efficacy of a low-fat diet as monotherapy or combined with prednisone remains poorly characterized.
In this prospective, observational cohort study of 14 dogs with presumptive PLE and ultrasonographic evidence of lymphangiectasia, subjects were placed on various low-fat diets as monotherapy and prednisone was added if response was deemed inadequate.
The dogs were assessed and scored at four recheck examinations across a six-month study period, including a final recheck ultrasound. Clinical and clinicopathologic variables were collected and dogs were divided into three outcome groups: clinical remission on dietary monotherapy (LOF), clinical remission on dietary therapy plus immunosuppressive prednisone (LOP) and treatment failure (TXF).
Eleven of 14 dogs were in clinical remission at the study end date (six months after enrollment), this included six LOF dogs and five LOP dogs.
LOF dogs achieved a significant reduction in Canine Chronic Enteropathy Clinical Activity Index score and a significant increase in serum albumin within two weeks of beginning dietary monotherapy. Four of 11 dogs in remission also had ultrasonographic evidence of resolution of linear striations.
In conclusion, the authors said a low-fat diet appears to be an effective monotherapy in some dogs with presumptive PLE and ultrasonographic evidence of lymphangiectasia.
Marc Myers, et al. “Prospective Evaluation of Low-Fat Diet Monotherapy in Dogs with Presumptive Protein-Losing Enteropathy.” J Am Anim Hosp Assoc. 2023 Mar 1;59(2):74-84. doi: 10.5326/JAAHA-MS-7248.
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