Primary intranasal perivascular wall tumors in cats
Perivascular wall tumors (PWTs) are common well-known canine mesenchymal tumors. The term PWT has not yet been applied to cats; only two cases of feline soft tissue hemangiopericytomas (HEPs) are available.
In human medicine, sinonasal HEP-like tumor/glomangiopericytoma (SHPCL/GP) and intranasal solitary fibrous tumor (SFT) are well-known mesenchymal tumors with staghorn vasculature and low malignant potential. However, these entities have not been described in small animals. The present study describes the pathologic and immunohistochemical features of two cases of feline intranasal mesenchymal tumors consistent with PWTs and resembling human SHPCL/GP (case one) and human intranasal SFT (case two).
Both cats developed intranasal, unilateral, polypoid, expansile neoplasms with a mostly patternless growth of spindle cells, minimal stroma and prominent staghorn vessels. The stroma was PAS negative, which excludes a glomus tumor. Immunohistochemistry identified diffuse vimentin and PDGFRβ expression. Case 1 was α-SMA positive (as is human SHPCL/GP); case 2 was negative (as is human intranasal SFT). Both tumors were incompletely excised, leading to recurrence in case one. Case two was lost to follow up.
To the authors knowledge, intranasal PWTs have not been reported previously in cats. The frequency of the lesions is not known, but awareness of these entities may assist in their recognition and better characterization in the future.
Francesco Godizzi, et al. “Primary intranasal perivascular wall tumors in 2 cats.” J Vet Diagn Invest. 2022 Nov 23;10406387221140074. doi: 10.1177/10406387221140074.
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