Articles Companion animals

24 July 2026

EXPRESS Comparing the Efficacy of Transmucosal and Subcutaneous Glucagon Administration in Response to Insulin-Induced Hypoglycemia in Healthy Cats.

Clinical evidence update from Journal of feline medicine and surgery

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for feline patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of feline medicine and surgery in 2026 evaluated eXPRESS: Comparing the Efficacy of Transmucosal and Subcutaneous Glucagon Administration in Response to Insulin-Induced Hypoglycemia in Healthy Cats..

Key Findings

ObjectivesTo evaluate the efficacy of two different formulations of glucagon given by three different routes (subcutaneous; SQ, rectal, intranasal; IN) for correcting insulin-induced hypoglycaemia in cats and to describe any adverse effects and compare the time required for administration by each route.MethodsA randomized, nonblinded, sham-controlled crossover study was conducted in six healthy cats, with a 7-day washout period between treatments. Hypoglycemia was induced using a continuous rate infusion (CRI) of rapid-acting Lispro insulin. Glucagon nasal powder (single-dose, ready-to-use) was given intranasally and rectally and compared to...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for feline patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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EXPRESS Comparing the Efficacy of Transmucosal and Subcutaneous Glucagon Administration in Response to Insulin-Induced Hypoglycemia in Healthy Cats.

Clinical evidence update from Journal of feline medicine and surgery

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