Prognostic factors in dogs with common causes of proteinuria

Little is known about the prognostic value of increased urine protein to creatinine ratios (UPC) comparing different underlying diseases in dogs. Therefore, between 2014 and 2015, dogs with a UPC of 2.0 or higher measured were retrospectively analyzed at least once.

The dogs were divided into groups of the most common underlying diseases, namely primary glomerulopathy, Cushing’s disease, leishmaniasis and in a group of different diseases. Possible prognostic factors, like UPC at time of diagnosis, creatinine, urine specific gravity, albumin and hematocrit, were assessed. Eighty-nine dogs with severe proteinuria were included in the study. Median time of survival was 42 days.

UPC and time of survival did not differ significantly between the groups. Among the dogs with primary glomerulopathy, researchers identified significant risk factors for death including increased UPC (p=0.03), increased creatinine (p<0.01), low hematocrit (p=0.04) and low urine specific gravity (p=0.03). In dogs with Cushing’s disease, only urine specific gravity was a significant risk factor for death (p<0.05). In dogs with leishmaniasis, increased UPC and creatinine were significant associated with mortality (p<0.01; p<0.01).

Increased UPC is a risk factor for death in dogs with primary glomerulopathy and leishmaniasis, but not in dogs with Cushing’s disease. This can be explained by different pathogenesis leading to proteinuria. 

Prognostic factors in dogs with common causes of proteinuria." F Baumgartner, et al. Schweiz Arch Tierheilkd. 2022 Jul;164(7):525-533.  doi: 10.17236/sat00362. 

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