Articles Companion animals

18 June 2026

Kinetics of Regenerating Protein 3E and C-Reactive Protein in Healthy Dogs, Dogs Undergoing Tibial Plateau Leveling Osteotomy, and Dogs With Sepsis.

Clinical evidence update from Veterinary clinical pathology

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for canine patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Veterinary clinical pathology in 2026 evaluated kinetics of Regenerating Protein 3E and C-Reactive Protein in Healthy Dogs, Dogs Undergoing Tibial Plateau Leveling Osteotomy, and Dogs With Sepsis..

Key Findings

Serial measurements of acute-phase proteins help monitor the development of and recovery from sepsis in people and dogs. To date, the kinetics of regenerating protein (REG) 3E, a novel biomarker for inflammation in dogs, are unknown. The goal of our study was to assess changes in the concentrations of REG3E and compare these to C-reactive protein (CRP) concentrations over 48-72 h in different cohorts of dogs. Plasma REG3E concentrations were measured using an ELISA on 3-4 consecutive days from 43 dogs, including 12 healthy controls, 17 undergoing tibial plateau leveling osteotomy (TPLO), and 14 with sepsis. Canine CRP was measured using a...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for canine patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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Kinetics of Regenerating Protein 3E and C-Reactive Protein in Healthy Dogs, Dogs Undergoing Tibial Plateau Leveling Osteotomy, and Dogs With Sepsis.

Clinical evidence update from Veterinary clinical pathology

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