MY ACCOUNT | NEWSLETTER |
HOME | Companion animals | Articles

Urine anion gap evaluation in healthy cats and cats with kidney disease

Ammonium excretion decreases as kidney function decreases in several species, including cats, and may have predictive or prognostic value in patients with chronic kidney disease (CKD). Urine ammonia measurement is not readily available in clinical practice, and urine anion gap (UAG) has been proposed as a surrogate test. The primary aim of this study was to evaluate the correlation between urine ammonia-to-creatinine ratio (UACR) and UAG in healthy cats and those with CKD; a second objective was to determine if a significant difference exists between UAG of healthy cats and cats with CKD.

Urine samples were collected by cystocentesis from healthy client-owned cats (n = 59) and those with stable CKD (n = 17). Urine electrolyte concentrations were measured using a commercial chemistry analyzer and UAG was calculated as ([sodium] + [potassium]) - [chloride]. Urine ammonia and creatinine concentrations had been measured previously using commercially available enzymatic assays and used to calculate UACR. Spearman's rank correlation coefficient between UAG and UACR was calculated for both groups. The UAG values of healthy cats and cats with CKD were assessed using the Mann-Whitney test (P < .05).

The UAG was inversely correlated with UACR in healthy cats (P < .002, r0 = -0.40) but not in cats with CKD (P = .55; r0 = -0.15). A significant difference was found between UAG in healthy cats and those with CKD (P < .001).

Finally, the UAG calculation cannot be used as a substitute for UACR in cats. The clinical relevance of UAG differences between healthy cats and those with CKD remains unknown.


“Correlation between urine anion gap and urine ammonia-creatinine ratio in healthy cats and cats with kidney disease”. Alyssa R Berman, et al. J Vet Intern Med. 2024 Feb 13.  doi: 10.1111/jvim.17002.

Source: https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.17002


Like0
Dislike0

Comments

  • Please enter a comment


Name *
Email address *
Comment *


* Required fields

Information on the processing of your personal data
We inform you that, in compliance with the provisions of current national and European regulations for the Protection of Personal Data and Services of the Information Society and Electronic Commerce, by sending us this form you are expressly giving your consent to Grupo Asís Biomedia , SL, (hereinafter, "ASIS GROUP") so that, as the person in charge, it may process your personal data in order to respond to your request for contact and information by electronic means.

Likewise, when you expressly consent, we will process your personal data to send you specialized information, newsletters, offers and exclusive promotions from GRUPO ASIS and related companies.

For the aforementioned purpose, GRUPO ASIS may transfer your data to other companies linked to GRUPO ASIS or to third party service providers for the management of electronic communications and other security services, even in cases where they are outside of the European Union, provided that they legally guarantee the adequate level of protection required by European regulations.

At any time you can withdraw the consent given and exercise the rights of access, rectification, deletion, portability of your data and limitation or opposition to its treatment by contacting GRUPO ASIS by sending an email to protecciondatos @ grupoasis.com, or by written communication to address at Centro Empresarial El Trovador, 8th floor, office I, Plaza Antonio Beltrán Martínez 1, 50002, Zaragoza (Spain), indicating in either case the Ref. Personal data and the right you exercise, as well as attaching a copy of your ID or replacement identification document.

I have read and accept the treatment of my data according to the informed purpose and according Legal notes and the Privacy Policy
I wish to receive commercial information from GRUPO ASIS and related companies

Tag

UrineAnion GapEvaluationHealthy CatsCatsKidney Disease

Related Articles

04 December 2023

Urine concentrating ability in cats with hyperthyroidism: Influence of radioiodine treatment, masked azotemia, and iatrogenic hypothyroidism
16 September 2022

Prognostic factors in dogs with common causes of proteinuria
24 August 2022

Urinary Protein/Creatinine Ratio in Feline Medicine: Reasons to Perform It and Its Role in Clinical Practice—A Retrospective Study
20 August 2022

Urine bacterial culture growth in cats with acute kidney injury
03 July 2022

Bacterial urinary tract infection and subclinical bacteriuria in dogs receiving antineoplastic chemotherapy

More news

Latest News Veterinary News

Research on key host pathways has implications for Ebola and beyond

Read more
Like0
Dislike0

Articles Companion animals

Anatomical classification of feline extrahepatic portosystemic shunts

Read more
Like0
Dislike0

Articles Ruminants

The role of endoscopy in bovine internal medicine

Read more
Like0
Dislike0

Use of levetiracetam for the treatment of myoclonic seizures in dogs

Read more
Like0
Dislike0

Latest News Veterinary News

Correlation

Read more
Like0
Dislike0

Newsletter

 
 

News of interest

Immunis Initiates Non-Terminal Preclinical Studies to Address Canine Muscle Atrophy
Outcome of canine trauma patients
Outcomes of dogs with apocrine gland anal sac adenocarcinoma treated surgically
Comparison of serum cortisol concentration in dogs with lymphoma

EVENTS

Copyright © 2024 - All Rights Reserved
ISSN 2768-198X

About Us Authors Contact Us Legal Notes Privacy Search

Top