MY ACCOUNT | NEWSLETTER |

Canine and feline P-glycoprotein deficiency


In 2001, the molecular genetic basis of so-called "ivermectin sensitivity" in herding breed dogs was determined to be a P-glycoprotein deficiency caused by a genetic variant of the MDR1 (ABCB1) gene often called "the MDR1 mutation."  

Researchers have learned a great deal about P-glycoprotein's role in drug disposition since that discovery, namely that P-glycoprotein transports many more drugs than just macrocyclic lactones and that P-glycoprotein mediated drug transport is present in more places than just the blood brain barrier. Scientists have also discovered that some cats have a genetic variant of MDR1 that results in P-glycoprotein deficiency and that P-glycoprotein dysfunction can occur as a result of drug-drug interactions in any dog or cat. It has also been determined that the concept of P-glycoprotein "inhibitors" versus P-glycoprotein substrates is somewhat arbitrary and artificial.  

In this paper, researchers review these discoveries and discuss how they impact drug selection and dosing in dogs and cats with genetically mediated P-glycoprotein deficiency or P-glycoprotein dysfunction resulting from drug-drug interactions.  

The team concluded that a strategic, collaborative effort is needed to characterize the P-gp status of the hundreds of drugs used to treat canine and feline patients, preferably prior to a drug being marketed. In doing so, the authors said that serious and potentially fatal adverse drug reactions in dogs and cats can be prevented.

Katrina L Mealey, Jane Owens and Elaine Freeman. “Canine and feline P-glycoprotein deficiency: What we know and where we need to go.” J Vet Pharmacol Ther. 2022 Nov 3. doi: 10.1111/jvp.13102.

Like0
Dislike0
  • Please enter a comment


Name *
Email address *
Comment *


* Required fields

Information on the processing of your personal data
We inform you that, in compliance with the provisions of current national and European regulations for the Protection of Personal Data and Services of the Information Society and Electronic Commerce, by sending us this form you are expressly giving your consent to Grupo Asís Biomedia , SL, (hereinafter, "ASIS GROUP") so that, as the person in charge, it may process your personal data in order to respond to your request for contact and information by electronic means.

Likewise, when you expressly consent, we will process your personal data to send you specialized information, newsletters, offers and exclusive promotions from GRUPO ASIS and related companies.

For the aforementioned purpose, GRUPO ASIS may transfer your data to other companies linked to GRUPO ASIS or to third party service providers for the management of electronic communications and other security services, even in cases where they are outside of the European Union, provided that they legally guarantee the adequate level of protection required by European regulations.

At any time you can withdraw the consent given and exercise the rights of access, rectification, deletion, portability of your data and limitation or opposition to its treatment by contacting GRUPO ASIS by sending an email to protecciondatos @ grupoasis.com, or by written communication to address at Centro Empresarial El Trovador, 8th floor, office I, Plaza Antonio Beltrán Martínez 1, 50002, Zaragoza (Spain), indicating in either case the Ref. Personal data and the right you exercise, as well as attaching a copy of your ID or replacement identification document.


I have read and accept the treatment of my data according to the informed purpose and according Legal notes and the Privacy Policy
I wish to receive commercial information from GRUPO ASIS and related companies



More news

Corneal calcareous degeneration and various ophthalmic diseases in dogs

Like0
Dislike0

Management of uroperitoneum through combination of conservative and surgical treatments in colts

Like0
Dislike0

Genetic Focus on Improving Animal Protein Sustainability

Like0
Dislike0

Multi-agency report highlights importance of reducing antibiotic use

Like0
Dislike0

Antiviral combination treatment in cats with feline herpesvirus-1 infection

Like0
Dislike0

Newsletter

 
 

News of interest

EVENTS

Copyright © 2024 - All Rights Reserved
ISSN 2768-198X

Top