Short-term postprandial changes in select serum biochemistry analytes in healthy adult cats
Objectives: The aim of this study was to evaluate the magnitude, duration and significance of postprandial changes to select serum biochemistry analytes in healthy adult cats in the 12-hour period after a meal.
Methods: Nine adult research cats fed commercial food were included in the study. Blood samples were taken after a 12 hour fast, cats were offered and consumed a meal, and postprandial samples were obtained over a 12-hour period starting two hours after the baseline blood draw.
Serum samples were run on a Roche Cobas C501 chemistry analyzer to obtain concentrations of blood urea nitrogen (BUN), creatinine, phosphorus, total calcium, bicarbonate, cholesterol, magnesium, sodium, potassium and chloride. Serum concentrations of each analyte at hours two, four, six, eight, 10 and 12 were compared with concentrations prior to feeding.
Results: Serum concentration for at least one postprandial time point was different from baseline fasted concentration for BUN (hour 2, P = 0.006; hour 4, P <0.0001; hour 6, P = 0.002; hour 8, P = 0.026), phosphorus (hour 2, P = 0.019), bicarbonate (hours 2, 4, 6, 8 and 10; all P <0.01), glucose (hour 12, P = 0.014), magnesium (hour 10, P = 0.029) and chloride (hour 2, P = 0.026; hour 4, P = 0.044; hour 12, P = 0.019). No significant difference was seen at any postprandial sampling point compared with baseline for serum creatinine, total calcium, cholesterol, sodium or potassium concentrations.
Conclusions and relevance: Short-term postprandial serum concentrations of BUN, phosphorus, bicarbonate and chloride differed at multiple time points within a 12-hour period compared with the fasted state at baseline, with most values remaining within the reference intervals.
Veterinarians should be aware of these alterations, though they are unlikely to be mistaken for pathological disease states in healthy adult cats.
Olivia Wallace, et al. “Short-term postprandial changes in select serum biochemistry analytes in healthy adult cats.” J Feline Med Surg. 2022 Oct 11;1098612X221121929. doi: 10.1177/1098612X221121929.
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