Current understanding of the pathophysiologic mechanisms of canine atopic dermatitis
Our thinking about the skin disease in dogs currently called AD has undergone immense changes in the past 75 years. First called eczema in dogs by Schnelle in 1933, it was later termed canine allergic inhalant dermatitis and then canine atopy. The skin disease associated with atopy in dogs is now referred to as canine AD.
Since the first description of this condition, huge strides have been made in human medicine, particularly in the biomedical sciences, with regard to how the immune system works. Basic scientific knowledge has crossed over into the field of clinical medicine, resulting in improved patient care. Much of what is understood about allergies in humans can be applied to veterinary patients, with the caveat that dogs are not humans.
Nevertheless, although there are species differences in some of the aspects of immune function among species, mammalian immune function is fairly consistent and some of the principles understood in human medicine can be applied to veterinary patients, always being careful to verify via research and clinical studies that the pathophysiologic mechanisms in humans hold true for species of interest in veterinary medicine. To understand the current knowledge on the pathophysiologic mechanisms of canine AD, preconceived notions must be put aside and the newer evidence-based information examined.
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Authors: Rosanna Marsella, Candace A. Sousa, Andrea J. Gonzales, Valerie A. Fadok
Source: https://avmajournals.avma.org/
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