Pharmacokinetics of mavacoxib in New Zealand White rabbits
The aim of the study was to characterize the pharmacokinetics of a single oral dose (6 mg/kg) of mavacoxib in New Zealand White rabbits (Oryctolagus cuniculus) and to characterize any clinicopathologic effects with this medication and dose.
Before drug administration, clinicopathologic samples were collected by the team for baseline data (CBC, serum biochemical analyses, and urinalysis including urine protein-to-creatinine ratio). All six rabbits received a single oral dose (6 mg/kg) of mavacoxib.
Clinicopathologic samples were collected at set time intervals to compare with the baseline. Plasma mavacoxib concentrations were determined using liquid chromatography with mass spectrometry, and pharmacokinetic analysis was performed using non-compartmental methods.
Six healthy, four-month-old New Zealand White rabbits (three male, three female) were enrolled in the study. After a single oral dose, the maximum plasma concentration (Cmax; mean, range) was 854 (713-1040) ng/mL, the time to Cmax (tmax) was 0.36 (0.17-0.50) days, the area under the curve from 0 to the last measured time point (AUC0-last) was 2000 (1765-2307) days*ng/mL, the terminal half-life (t1/2) was 1.63 (1.30-2.26) days, and the terminal rate constant (λz) was 0.42 (0.31-0.53) days. All results for CBCs, serum biochemical analyses, urinalyses, and urine protein-to-creatinine ratios remained within published normal reference intervals.
In conclusion, this study determined that plasma concentrations reached target levels of 400 ng/mL for 48 hours in three of six rabbits at 6 mg/kg PO. In the remaining three rabbits, the plasma concentrations were 343-389 ng/mL at 48 hours, which is below the target concentration.
The authors said that further research is needed to make a dosing recommendation, including a pharmacodynamic study and investigating pharmacokinetics at different doses and multiple doses.
Sarah E Wilson, et al. “Pharmacokinetics of mavacoxib in New Zealand White rabbits (Oryctolagus cuniculus).” Am J Vet Res. 2023 Apr 3;1-5. doi: 10.2460/ajvr.22.11.0196.
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