Multisystemic eosinophilic epitheliotropic disease in three donkeys
Multisystemic eosinophilic epitheliotropic disease (MEED) is a rare condition of equids characterized by eosinophilic infiltration of multiple organs. Clinical signs are variable depending on the affected organs.
The most common clinical signs include chronic weight loss, diarrhea and exfoliative dermatitis. Respiratory distress and raised liver enzymes are less frequently seen. The cause is unknown, and the pathogenesis is poorly understood.
There are less than 50 reported cases of horses with MEED.
In this paper, the authors document the lesions in three donkeys with fluctuating or chronic loss of weight, lethargy, exfoliative dermatitis and peripheral eosinophilia. All three animals were euthanized due to poor prognosis and welfare concerns.
Post-mortem examination revealed multiple white to tan, irregular masses composed of eosinophilic infiltrates, including eosinophilic granulomas in several organs, confirming the presence of MEED. To the best of the authors’ knowledge, MEED has not previously been reported in donkeys.
Georgios Paraschou et al. “Multisystemic eosinophilic epitheliotropic disease in three donkeys.” J Comp Pathol. 2023 Feb 13; 201:105-108. doi: 10.1016/j.jcpa.2023.01.005.
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