Articles Companion animals

17 July 2026

Association of impaired ammonia excretion with survival in dogs with stable chronic kidney disease.

Clinical evidence update from Journal of veterinary internal medicine

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for canine patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of veterinary internal medicine in 2026 evaluated association of impaired ammonia excretion with survival in dogs with stable chronic kidney disease..

Key Findings

In people with chronic kidney disease (CKD), inadequate renal ammonia excretion contributes to metabolic acidosis and is associated with worse outcomes. However, the prognostic relevance of ammonia excretion in dogs with CKD remains unclear. A reduced urine ammonia-to-creatinine ratio (UACR) would be associated with shorter survival and faster disease progression in dogs with stable CKD. Fifty client-owned dogs with International Renal Interest Society (IRIS) stages II-IV CKD receiving a therapeutic renal diet. Prospective, observational longitudinal study. Dogs were followed for up to 12 months or until death. Progressive CKD was defined as...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for canine patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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Association of impaired ammonia excretion with survival in dogs with stable chronic kidney disease.

Clinical evidence update from Journal of veterinary internal medicine

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