Comparison of alfaxalone, propofol on hematological and serum biochemical variables in cats undergoing radiotherapy
Objective: To evaluate effects of repeated alfaxalone or propofol administration on hematological and serum biochemical variables in cats undergoing radiotherapy.
Study design: Prospective, block-randomized, clinical trial.
Animals: A group of 39 client-owned cats.
Methods: After butorphanol (0.2 mg kg-1) and midazolam (0.1 mg kg-1) sedation, cats were randomly assigned to receive either alfaxalone or propofol for induction of anesthesia and sevoflurane maintenance. Cats were anaesthetized daily with the same induction agent for 10-12 days. Complete blood counts, reticulocytes, Heinz body score and serum biochemistry were performed before the first treatment (T1), at T6, T10 and 3 weeks after the final treatment (T21). Cumulative induction agent dose for each cat at each time point was evaluated for an effect on Heinz body score. Data are shown as mean ± standard deviation; p < 0.05.
Results: At baseline there were no significant differences in signalment or blood variables between groups. A significant decrease in hematocrit of 2.3% ± 0.77 (p = 0.02) between T1-T6 and T1-T10 [mean 4.1% (± 0.78, p < 0.0001)] was detected, with a significant increase in hematocrit of 2.1% ± 0.80 (p = 0.046) between T6-T21 and 4.0% ± 0.8 (p < 0.001) between T10-T21. Heinz body score significantly increased by 1.86 ± 0.616 (p = 0.013) between T1-T10. In the propofol group, reticulocytes increased significantly between T1-T6 [mean 23,090 μL-1 ± 7670 (p = 0.02)] and T1-T10 [mean 27,440 μL-1 ± 7990 (p = 0.007)]. Mean cumulative dose at T10 was 19.65 mg kg-1 ± 5.3 and 43.4 mg kg-1 ± 14.4 for alfaxalone and propofol, respectively, with no significant effect on Heinz body formation at any time point.
Conclusions and clinical relevance: Hematocrit decreased in both groups with recovery after three weeks. Repeated alfaxalone and propofol administration was not associated with marked hematological or serum biochemistry changes.
Maximilian Körner et al. "Comparison of alfaxalone and propofol on haematological and serum biochemical variables in cats undergoing radiotherapy with sevoflurane maintenance." Vet Anaesth Analg. 2023 Mar;50(2):146-156. doi: 10.1016/j.vaa.2022.11.010. Epub 2022 Nov 26.
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