Serum uromodulin in dogs with chronic kidney disease
Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs. The aim of this study was to evaluate the serum uromodulin concentration in dogs with CKD and assess its diagnostic performance in distinguishing dogs with CKD from healthy dogs.
Serum uromodulin concentration was measured using a canine-specific enzyme-linked immunosorbent assay (ELISA), and its correlation with conventional renal markers was analyzed.
The study included 49 dogs with CKD and 25 healthy dogs as a control group. Serum uromodulin concentrations were significantly lower in the CKD group than in the control group (P < .001), but no significant difference was observed among stages of CKD.
A negative correlation was observed between serum uromodulin concentration and conventional renal markers. In receiver operating characteristic analysis, the area under the curve (AUC) of uromodulin was higher than that of SDMA for CKD diagnosis.
The AUC of uromodulin was also higher than that of SDMA in distinguishing dogs with Stage 1 CKD from controls.
In conclusion, serum uromodulin concentration is decreased in dogs with CKD. Thus, serum uromodulin may be a valuable diagnostic marker for CKD in dogs, particularly in identifying early-stage CKD
Dansong Seo et al. “Serum uromodulin in dogs with chronic kidney disease.” J Vet Intern Med. 2022 Nov;36(6):2071-2078. doi: 10.1111/jvim.16579.
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