Serum concentrations of feline pancreatic lipase immunoreactivity (fPLI), feline trypsin-like immunoreactivity (fTLI) and cobalamin are commonly used for the diagnostic investigation of cats with gastrointestinal signs. No information exists on these parameters in healthy cats less than one year of age. This study aimed to evaluate serum concentrations of fPLI, fTLI and cobalamin in healthy cats at different time-points during the first 12 months of life.
Fourteen healthy two-month-old kittens were included in the study. Blood was collected at two, three, four, six and 12 months of age. The research team measured serum concentrations of fPLI, fTLI and cobalamin.
Result showed that, while there was a statistically significant difference in serum fPLI concentrations over time, there was no statistically significant difference between individual time-points. There was no significant difference in serum fTLI concentrations over time.
Serum cobalamin concentrations were below the reference interval in three of 13 cats at two months of age and were significantly lower by three months, when 13 of 14 had hypocobalaminemia. By 12 months, serum cobalamin had significantly increased, yet four of 12 cats still had hypocobalaminemia.
The research team concluded that serum fPLI and fTLI concentrations did not show any statistically or clinically significant differences in young kittens. In contrast, serum cobalamin concentrations were commonly below the reference interval in kittens.
Serum fPLI and fTLI concentrations are not practically affected by age in kittens as young as two months of age and could be used for the investigation of pancreatic diseases.
Stavroulaki, Evangelia M. et al. “Serial Measurement of Serum Pancreatic Lipase Immunoreactivity, Feline Trypsin-like Immunoreactivity, and Cobalamin Concentrations in Kittens.” Veterinary Sciences. 2022 Aug 31; 9(9):469. doi: 10.3390/vetsci9090469.
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