Effect of standard-dose and high-dose pimobendan on select indices of renal and cardiac function in dogs

Pimobendan might have favorable effects on renal function, but this has not been well-studied in dogs with myxomatous mitral valve disease (MMVD). The aim of the study was to determine the effects of standard-dose (SD_pimo) and high-dose pimobendan (HD_pimo) on glomerular filtration rate (GFR) and cardiac size and function in dogs with preclinical MMVD.  

Thirty nonazotemic dogs with stage B2 MMVD was enrolled in this prospective, randomized, double-blinded, placebo-controlled clinical study. Dogs had an echocardiographic examination, assessment of GFR (iohexol clearance), N-terminal probrain natriuretic peptide (NT-proBNP), and quality of life (QOL) score at baseline and 7 to 10 days after placebo (n = 6), SD_pimo 0.2 to 0.3 mg/kg q12 (n = 12), or HD_pimo 0.5 to 0.6 mg/kg q12h (n = 12).  

Data showed that no significant differences in GFR or QOL scores were detected between groups (P ≥ .07). After HD_pimo, the mean [SD] percent change of NT_proBNP (-46.1 [20.2]%), left atrial volume (LAV; -27.1 [16.9]%), left ventricular end-diastolic volume (EDV; -21.8 [15.0]%), and end-systolic volume (ESV; -55.0 [20.7]%) were significantly different (P ≤ .004) from placebo (0.5 [19.9]%, 1.3 [15.6]%, -0.2 [8.2]%, -7.3 [35.6]%, respectively) but not the percent change after SD_pimo (-36.6 [16.1]%, -22.7 [14.9]%, -16.7 [12.5]%, -41.6 [14.8]%, respectively; P > .05). After SD_pimo, percent change of NTproBNP, LAV, EDV, and ESV were significantly different from placebo (P < .05).  

The authors said results suggest that pimobendan might not affect renal function in nonazotemic dogs with stage B2 MMVD. High dose pimobendan did not demonstrate advantages over SD_pimo within the constraints of the study.

Joanna L Kaplan, et al. “Effect of standard-dose and high-dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease.” J Vet Intern Med. 2022 Sep 13. doi: 10.1111/jvim.16537

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