Articles Companion animals

21 August 2026

A Multicenter Observational Study Comparing Survival of Pugs and Dogs of Other Breeds With Protein-Losing Enteropathy.

Clinical evidence update from Journal of veterinary internal medicine

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for canine patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of veterinary internal medicine in 2025 evaluated a Multicenter Observational Study Comparing Survival of Pugs and Dogs of Other Breeds With Protein-Losing Enteropathy..

Key Findings

Protein-losing enteropathy (PLE) in dogs often carries a guarded prognosis, and it is unclear if survival differs among breeds. Survival of pugs with PLE is shorter than that of other breeds of dogs with PLE. Forty-seven pugs and 148 dogs of other breeds were diagnosed with PLE at seven United Kingdom (UK) referral hospitals. Retrospective, multicenter observational study. Case records were reviewed to identify dogs diagnosed with PLE. Cox's proportional hazards regression was used to determine variables associated with survival. Median (interquartile range) survival in pugs with PLE and dogs of other breeds was 104 (22-719) days and 759...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for canine patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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A Multicenter Observational Study Comparing Survival of Pugs and Dogs of Other Breeds With Protein-Losing Enteropathy.

Clinical evidence update from Journal of veterinary internal medicine

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