Articles Companion animals

21 August 2026

EXPRESS Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.

Clinical evidence update from Journal of feline medicine and surgery

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for feline patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of feline medicine and surgery in 2026 evaluated eXPRESS: Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats..

Key Findings

To determine the frequency and clinical significance of discordant serum symmetric dimethylarginine (SDMA) and creatinine concentrations relative to glomerular filtration rate (GFR) in mature and senior hyperthyroid cats treated with radioactive iodine (RAI). Further, to compare the sensitivity and specificity of two SDMA upper reference limits (>14 and ≥18 µg/dL) and creatinine (≥175 µmol/l) for detecting decreased GFR and evaluate the intra-individual variability of both biomarkers. A prospective longitudinal study of 27 client-owned hyperthyroid cats receiving low-dose RAI therapy. At baseline, one, six, and 12 months post-RAI, cats were...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for feline patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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EXPRESS Longitudinal evaluation of discordant symmetric dimethylarginine and creatinine as markers of glomerular filtration rate in radioiodine-treated hyperthyroid cats.

Clinical evidence update from Journal of feline medicine and surgery

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