Nasal lymphoma in cats treated with chlorambucil and prednisolone
Nasal lymphoma is the most common type of cancer of the nasal cavity in cats. Typically, veterinarians use radiation therapy and injectable chemotherapy, or both, to treat the lymphoma.
Chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine prednisolone) and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). Thus far, the use of single agent chlorambucil in nasal lymphoma has been evaluated in a single case report.
Here, the authors report a case series of three cats with B cell nasal lymphoma, two cats with intermediate cell, and one large cell, all with a low mitotic index (MI) of less than five mitotic figures per ×400 field, treated with chlorambucil and prednisolone.
The results revealed that two of the cases achieved a long disease-free interval, while the one with the highest MI did not.
The authors conclude that protocols using chlorambucil and prednisolone may have potential as a first-line therapy for feline nasal lymphoma cases with a very low mitotic index.
Karen W L Ng, Julia Beatty, May P.Y. Tse and Antonio Giuliano. “Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone.” Vet Sci. 2022 Sep 1;9(9):472. doi: 10.3390/vetsci9090472
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