Changes in rabbit lymphocyte populations following administration of meloxicam

Meloxicam is a commonly used analgesic in rabbits. However, its possible impact on lymphocyte subpopulations remained unknown. The aim of the study was to investigate a possible effect of long-term administration of meloxicam on rabbit lymphocyte subpopulations.

The study included eight rabbits given meloxicam orally once daily (1 mg/kg BW) for 14 days and eight rabbits as a control group. Researchers collected peripheral blood samples on day zero before the first dose of meloxicam, day three, seven and 14. Samples were evaluated with a hematology analyzer and a flow cytometer.

The research team found a significant decrease in T: B cell ratio in all samples taken during meloxicam administration compared to day zero, as well as in comparison with the control group (P < 0.01). A significant increase (P < 0.05) in proportion of CD5 +CD8 + lymphocytes occurred by day three. Subsequently, although the values slightly decreased, they remained elevated throughout all the experiment compared to the values from day zero (P < 0.05).

Researchers noted a slight decrease in T and B cell activation (CD5 +CD25 + and IgM+CD25 +) by day three, which declined during the next days of administration and became increasingly significant (finally, P = 0.0078).

In conclusion, since a high significant decrease (P < 0.01) in both T and B cell activation as well as a significant increase (P < 0.05) in CD5 +CD8 + T cells proportion were observed after meloxicam administration, a predicted effect of long-term administration of meloxicam on rabbit lymphocytes was confirmed.

Pavla Hamouzová, et al. “Changes in rabbit lymphocyte subpopulations and activation following long-term administration of meloxicam.” Vet Immunol Immunopathol. 2022 Sep 22; 253:110496. doi: 10.1016/j.vetimm.2022.110496.

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