Articles Companion animals

24 August 2026

Treatment of canine otitis externa a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product.

Clinical evidence update from Frontiers in veterinary science

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for canine patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Frontiers in veterinary science in 2026 evaluated treatment of canine otitis externa: a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product..

Key Findings

Erythemato-ceruminous otitis externa (ECOE) is a canine inflammatory condition very frequently involving secondary microbial infections. This multicentric, masked, randomized, clinical field trial in Japan evaluated the efficacy and safety of a hydrocortisone aceponate (HCA) spray solution (Cortotic™, Virbac, France) compared to a terbinafine/florfenicol/betamethasone acetate ear gel (Osurnia™, Bussan Animal Health CO Ltd, Japan) in 200 dogs with ECOE (OTIS3 ≥ 5). Dogs received either Cortotic™ daily for 7 or 14 days or Osurnia™ on Days 0 and 7. OTIS3 clinical evaluation and cytological examinations were conducted, as well as the subjective...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for canine patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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Treatment of canine otitis externa a randomized, double-blinded, clinical field study comparing the hydrocortisone aceponate monotherapy to a multi-agent reference product.

Clinical evidence update from Frontiers in veterinary science

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