Articles Companion animals

01 July 2026

Risk factors associated with elevated serum canine pancreatic lipase immunoreactivity concentration in dogs with hypercortisolism.

Clinical evidence update from Journal of veterinary internal medicine

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for canine patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of veterinary internal medicine in 2026 evaluated risk factors associated with elevated serum canine pancreatic lipase immunoreactivity concentration in dogs with hypercortisolism..

Key Findings

Hypercortisolism (HC) is a common endocrine disorder in dogs that is often associated with pancreatitis. However, the relationship between cortisol concentration, pancreatic injury (PI) markers, and serum specific canine pancreatic lipase immunoreactivity (Spec cPL) concentration elevation remains unclear. To investigate the prevalence of PI, identify risk factors for elevated Spec cPL, and evaluate changes in Spec cPL concentrations after treatment. Seventy-one client-owned dogs diagnosed with naturally occurring HC between 2015 and 2024. Retrospective cross-sectional study with a nested cohort analysis. Dogs were classified as PI (Spec cPL...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for canine patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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Risk factors associated with elevated serum canine pancreatic lipase immunoreactivity concentration in dogs with hypercortisolism.

Clinical evidence update from Journal of veterinary internal medicine

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