Articles Companion animals

10 June 2026

EXPRESS: Serum vitamin D metabolites do not differ between cats with chronic kidney disease and healthy cats.

Clinical evidence update from Journal of feline medicine and surgery

Clinical Context

Peer-reviewed veterinary literature continues to shape everyday decision-making for feline patients, especially when new evidence clarifies diagnosis, treatment selection, monitoring, or clinical outcomes.

What the Study Evaluated

A study published in Journal of feline medicine and surgery in 2026 evaluated eXPRESS: Serum vitamin D metabolites do not differ between cats with chronic kidney disease and healthy cats..

Key Findings

To characterize comprehensive vitamin D metabolite profiles in cats with chronic kidney disease (CKD) compared to healthy cats. Thirty-three healthy cats and 66 cats with CKD (6 IRIS Stage 1, 36 IRIS Stage 2, 18 IRIS Stage 3, 6 IRIS Stage 4) were prospectively enrolled. Serum vitamin D metabolites, including 25-hydroxyvitamin D3 (25[OH]D3), 3-epi-25-hydroxyvitain D3 (3-epi-25[OH]D3), 1,25-dihydroxyvitamin D3 (1,25[OH]2D3; calcitriol), and 24,25-dihydroxyvitamin D3 (24,25[OH]2D3) were analyzed via LC-MS/MS. Vitamin D metabolites, clinicopathologic parameters, age, body weight and body condition score were compared between groups using a Mann...

Why It Matters for Veterinary Professionals

For veterinary professionals, the practical value of this work lies in how the findings may support more structured clinical assessment, clearer monitoring, and more informed decisions for feline patients.

Practical Interpretation

The results should be interpreted in the context of the study design, population, inclusion criteria, and clinical setting. Application in practice should consider patient-specific risk factors, available diagnostics, local standards of care, and clinician judgment.

Clinical Takeaway

Overall, the study adds useful evidence for clinicians seeking to align daily practice with current veterinary research while maintaining a balanced, case-by-case approach.

Read the full article here.

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EXPRESS: Serum vitamin D metabolites do not differ between cats with chronic kidney disease and healthy cats.

Clinical evidence update from Journal of feline medicine and surgery

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