Serum amyloid A, clinicopathological variables in cats with lymphoma
Serum amyloid A (SAA) concentrations are increased in cats with lymphoma compared with healthy cats. However, the association between SAA concentrations and prognosis in cats with lymphoma is unclear. The aim of this study was to evaluate if SAA concentrations were different in cats with nasal versus non-nasal lymphoma, if SAA concentrations are prognostic in patients treated with high-dose chemotherapy and if SAA concentrations are correlated with other clinicopathological variables.
Cats diagnosed with intermediate- or large-cell lymphoma between 2012 and 2022 with SAA concentration data available were included in this study. Researchers evaluated associations between tumor site, stage, response to treatment and SAA concentration using non-parametric statistics. The team also analyzed associations between SAA concentrations and stage with survival time using Cox regression analysis. Patients with nasal tumors and those not receiving high-dose chemotherapy were excluded from the survival analyses.
Thirty-nine cats were evaluated for the study. Median SAA concentrations were significantly higher in non-nasal compared with nasal lymphoma. SAA concentrations did not correlate with tumor stage.
Median survival time for patients with non-nasal tumor and undergoing chemotherapy was 49 days. Responders had a better median survival time than non-responders, whereas SAA concentrations were not associated with survival time. Lower hematocrit at presentation was associated with a reduced median survival time.
The study authors found, in the population examined, no correlation between serum concentration of SAA and prognosis in patients with lymphoma, while low hematocrit and lack of response to treatment were both found to be associated with survival time. SAA concentrations were elevated in patients with non-nasal lymphoma vs patients with tumors confined to the nasal cavity.
Luca Schiavo, et al. “Serum amyloid A and other clinicopathological variables in cats with intermediate- and large-cell lymphoma.” J Feline Med Surg. 2022 Nov 23;1098612X221135118. doi: 10.1177/1098612X221135118.
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