Polyuria and polydipsia in dogs treated for atopic dermatitis
Glucocorticoids are commonly used to treat canine allergic disorders, but they frequently cause polyuria and polydipsia (PUPD). At equipotent dosages, oral methylprednisolone is believed to cause less PUPD than prednisolone.
The authors performed a pilot randomized, open, parallel trial with 22 dogs with nonseasonal atopic dermatitis (AD) receiving either prednisolone or methylprednisolone at equipotent dosages, once daily for 14 days during the first phase of a restriction-provocation dietary trial. Before and on days three, seven, and 14 after starting the glucocorticoids, owners estimated water consumption for 24 hours. On the same days and before the glucocorticoid was given, owners collected the first-morning urine to determine the urine specific gravity (USG).
There were no significant differences between the prednisolone and methylprednisolone groups on days three, seven and 14 when comparing the changes in water intake from baseline. Most dogs from both groups exhibited a slight reduction in USG during the study. Still, there was no significant difference in USG changes between the groups on any of these three reevaluation days.
Researchers concluded that the administration of two weeks of oral prednisolone and methylprednisolone at equipotent anti-inflammatory dosages at the beginning of an elimination diet did not lead to significant differences in water intake and USG.
Viktorija Lokianskiene, et al. “A Pilot Randomized Trial to Compare Polyuria and Polydipsia during a Short Course of Prednisolone or Methylprednisolone in Dogs with Atopic Dermatitis.” Vet Sci. 2022 Sep 9;9(9):490. doi: 10.3390/vetsci9090490.
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