Tonometers for measuring intraocular pressure in rabbits
among the three tonometers tested, the TonoVet tonometer is best for use in rabbits
The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24 rabbits. Additionally, the impact of sedation on IOP was investigated in 21 New Zealand White rabbits with the TonoVet tonometer. Repeatability was determined using the coefficient of variation (CoV) for two observers. For the TonoLab (6.55%) and TonoVet (6.38%) the CoV was lower than for the TonoPEN AVIA (10.88%). The reproducibility was highest for the TonoVet (0.2 ± 3.3 mmHg), followed by the TonoLab (0 ± 12.89 mmHg) and lowest for the TonoPEN AVIA (- 1.48 ± 10.3 mmHg). The TonoLab and TonoVet showed the highest agreement (r = 0.85, R2 = 0.73). After sedation, a significant IOP reduction (often > 25%) was observed. Our results show that among the three tonometers tested, the TonoVet tonometer is best for use in rabbits while the TonoLab should be avoided. The impact of sedation on IOP was substantial and should be taken into account during experimentation.
“Repeatability, reproducibility, and agreement of three tonometers for measuring intraocular pressure in rabbits”. Sci Rep. 2021 Sep 28;11(1):19217. doi: 10.1038/s41598-021-98762-7. Christian J F Bertens, et al.
Comments
Related Articles
Copyright © 2024 - All Rights Reserved
ISSN 2768-198X
List
Add
Please enter a comment