Use of Trimethoprim-sulfonamide in foals
Trimethoprim-sulfonamide (TMPS) combinations are widely used to treat a range of infectious diseases in horses, but some equine practitioners are reluctant to use them for treatment of both neonatal and older foals. Considering the emergence of increased antimicrobial resistance, the use of protected antimicrobials commonly prescribed to foals should be avoided and alternative first-line therapy considered, where appropriate. This review examines the characteristics and pharmacokinetics of TMPS and its suitability for treatment of foals.
Data regarding dosage and route of administration are reported on the basis of recent publications in foals. The review intends to share significant information about the common infections that are most likely responsive to TMPS treatment in foals and, as such, where TMPS might be considered a suitable first-line therapeutic option.
Trimethoprim-sulfonamide combinations are safe to administer to foals and without reported side effects when administered at a dosage of 24 mg/kg every 12 hours PO or 15 mg/kg every 12 hours IV. The oral dosage of 24 mg/kg every 12 hours PO reaches serum/plasma concentrations above MIC90 for relevant pathogens. Bacterial susceptibility is variable and varies considerably among geographical areas and laboratory facilities
“Trimethoprim-sulfonamide: a valid antimicrobial treatment in foals?”. Kajsa Gustafsson, et al. J Am Vet Med Assoc. 2024 Mar 13:1-9. doi: 10.2460/javma.23.09.0536.
Source: https://avmajournals.avma.org/view/journals/javma/aop/javma.23.09.0536/javma.23.09.0536.xml
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