Changes in acute phase response biomarkers in racing endurance horses

This study aimed to evaluate if exercise-induced acute phase response (APR) occurs in endurance horses in response to the race. 

The study included 23 horses competing in an endurance competition. The horse had successfully passed the clinical examination before the race. Blood samples were collected before the start and within 30 minutes after the end of the race. Hematological and biochemical tests were performed and correlated to acute phase biomarkers changes. 

Results showed that values of calprotectin and haptoglobin (Hp) decreased after the races compared to values before, while concentrations of ceruloplasmin and albumin increased significantly. Greater changes in calprotectin values were noted in Arabian horses compared to other breeds. Values of Hp showed a significantly greater decrease after longer races. 

In conclusion, based on the study results, the authors said that endurance racing induces APR in horses, characterized by significant changes in selected acute phase biomarkers. More pronounced changes were noted at races with higher average speeds, suggesting the need for thorough horse monitoring during exhausting races.

Karla Mihelić, et al. “Changes in Acute Phase Response Biomarkers in Racing Endurance Horses.” Animals (Basel). 2022 Oct 31;12(21):2993. doi: 10.3390/ani12212993.

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