Toceranib phosphate in the management of canine insulinoma
Insulinomas are the most common tumour of the endocrine pancreas in dogs. These malignant tumors have a high metastatic rate and limited chemotherapeutic options. The multi-receptor tyrosine kinase inhibitor sunitinib malate has benefits in the treatment of metastatic insulinoma in people. Toceranib phosphate, an analogous veterinary agent, may provide benefits for dogs.
A retrospective study describing the extent and duration of clinical outcomes and adverse events (AEs) in dogs diagnosed with insulinoma and receiving toceranib.
Records for 30 dogs diagnosed with insulinoma and having received toceranib were identified from a medical record search of five universities and eight referral hospitals. The median progression-free interval and overall survival time were 561 days (95% confidence interval (CI): [246, 727 days]) and 656 days (95% CI: [310, 1045 days]), respectively. Of the dogs for which the canine Response evaluation criteria for solid tumors tool could be applied, the majority (66.7%) showed either a complete response, partial response, or stable disease. Time to clinical progression was associated with prior intervention and type of veterinary practice. Larger dogs were at increased risk for disease progression and death. No novel AEs were reported.
Most dogs diagnosed with insulinoma and receiving toceranib appeared to have a clinical benefit. Randomised, prospective studies are needed to better elucidate and objectively quantify the potential effect and survival benefit of toceranib therapy for the management of insulinoma in dogs.
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